“A Coming Covid Catastrophe” – Geert Vanden Bossche, DVM, PhD Virology

Dr. Geert Vanden Bossche, DVM, PhD virology, independent seasoned vaccine researcher, previous SPO at the Bill & Melinda Gates Foundation and SPM at GAVI is urging WHO and world political leaders to immediately halt all ongoing Covid-19 mass vaccination campaigns as there is compelling evidence that they will soon dramatically worsen the consequences of the current pandemic. Geert Van Bossche is stating the mass vaccinations will result in mass casualties among all humans of all ages!

Highlights:

– We must halt all ongoing Covid-19 mass vaccination campaigns as a temporary health benefit to the most vulnerable groups does not justify a public health disaster of international concern.

– I do not think that it is reasonable for WHO or any other health authority to approve ‘emergency use’ of vaccines aimed at conducting mass vaccination campaigns in the very heat of an infectious pandemic without having gained an in-depth understanding of how this may impact on the outcome of the pandemic.

– In particular, lack of understanding of the consequences of immune pressure on highly mutable viruses has now allowed for the approval of a number of Covid-19 vaccines that are completely contraindicated for fighting a pandemic, regardless of the technology used. Although safe and efficacious and providing temporary relief to part of the population and to healthcare facilities, these vaccines will soon come with a heavy toll to be paid by the entire population if mass vaccination campaigns continue.

– Clearly, the upcoming manuscript is not meant to be submitted to a scientific peer-reviewed journal but to explain the scientific rationale behind my cry of distress and urgent wake-up call. May they for God’s sake draw the world’s attention to what I think is now likely to become the biggest and most tragic mistake made in the history of public health in general and in the field of vaccination in particular.

– In the meantime, these disastrous vaccination campaigns will likely be intensified and even extended to younger age groups. Given the power, influence and blind ambition of the stakeholders driving these campaigns, it is going to be incredibly difficult to stop this act of complete madness. When all of them will finally have to admit the catastrophic consequences of this ‘experiment’, precious time and, more importantly, many more lives will have been lost. Eventually, complete lockdowns will likely be imposed for an undefinite period of time as a last resort.

– I cannot emphasize enough that continuing these vaccination endeavors will dramatically prolong, instead of shorten, the current pandemic and take a much higher toll in terms of disease and fatality rates in all of the population. It goes without saying that a such enhancement of this crisis will come with unbearable socio-economic consequences for many years to come.

– The manuscript will provide compelling evidence that – as far as acute self-limiting viral infections are concerned – the natural course (i.e., without human intervention!) of a Coronavirus pandemic is typically featured by 3 waves that ultimately flatten as the infection merges into a seasonal ‘common cold.’ However, it is difficult to predict how long it would take a natural Covid-19 pandemic to ‘downgrade’ to yet another kind of seasonal ‘common cold’ without human intervention.

– Given the huge amount of immune escape that will be provoked my mass vaccination campaigns and flanking containment measures, it is difficult to imagine how human interventions would not cause the Covid-19 pandemic to turn into an incredible disaster for global and individual health.

– In contrast, all of the current Covid-19 vaccines rely on strengthening adaptive (as opposed to innate) immunity in general, and humoral (i.e. antibodies) in particular. Hence, none of them will prevent immune escape and, for that matter, all will be subject to anti-viral resistance. Adapting the composition to the new circulating variants does not solve the problem as science tells us that this will even accelerate the rate of immune escape (in asymptomatic Covid-19 carriers).

– Isn’t it surprising that while we have now become so well aware of all dramatic consequences and threats surrounding microbial resistance to antibiotics, we still don’t believe that fighting viruses in ways that do not completely kill them opens the door to vaccine resistance?

– Widespread use of antibiotics is generally acknowledged to raise a serious global concern about antimicrobial resistance, but nobody seems to bother about resistance to vaccines that are used in mass vaccination campaigns in the context of an ongoing pandemic. Since those are conducted against a huge infectious background, a multitude of vaccinees will be in the process of seroconverting while being exposed to circulating infectious virus.

– Prophylactic vaccines against viral or other infectious diseases are typically administered well in advance of a likely risk of infectious exposure. While this is ensuring full-fledged protection to the infectious agent, it is also preventing immune escape and hence, resistance to the vaccine. Aren’t we not already witnessing an increasing number of cases of Covid-19 vaccinated people who still shed virus and sometimes even develop mild symptoms? Aren’t these cases compelling enough in proving how easily Covid-19 viruses can escape antibody responses? How can we then be so excited about current Covid- 19 vaccines knowing that they allow immune escape and thus, enable the virus to select more infectious variants? And do we really think that going for a one dose shot (instead of the prescribed 2-dose vaccination schedule), as some propose, is not going to even expedite immune escape?

– By implementing immune intervention strategies that capitalize on empowering these innate immune cells to acquire immunologic memory, it must be possible to fully, broadly and durably protect human populations against all Covid-19 editions, and even against Coronaviruses at large. The ‘sterilizing’ immunity they provide would not only protect people who would ‘naturally’ become asymptomatically infected (but, unfortunately, only enjoy natural protection for as long as they keep their innate immune system well-trained through moderate but regular pathogen exposure) but also subjects who would ‘naturally’ develop (severe) symptoms or even succumb to the disease.

– In conclusion, fostering the development of NK cell-based vaccines should become a public health priority. As will become obvious from the manuscript, NK-cell based hold great promise for stopping this pandemic at its source while also ensuring future preparedness to emerging pandemic threats at large.

– The first wave of disease1 (and mortality) primarily affects elderly people (or otherwise immunocompromised subjects). Selective (i.e., adaptive) immune escape is expected to cause this wave to transition into a more severe, second wave in younger age groups. Subsequently, non-selective (i.e., innate) as well as selective immune escape operated by increasingly infectious viral variants will trigger a third wave. The latter would primarily affect subjects who recovered from disease they contracted during the first wave as their seroneutralising Abs do no longer properly match the new circulating viral variants.

– This third wave of disease (and mortality) would come to an end when those who recovered from the disease will have mounted new functional Abs against these immune escape variants. As seroconversion in this population will now occur much faster (due to recall of cross-reactive T helper memory cells) and as the majority of the young and middle-aged population will either be seronegative or have seroconverted already by the time the third wave starts to expand, chances are slim for the virus to escape the host’s Ab response.

– Asymptomatic2, seronegative individuals (i.e., the vast majority of young and middle-aged people) may spread virus upon (re-)infection and hence, constitute a relevant source of viral transmission. However, CoV infection in these asymptomatic carriers is abrogated after a short period of viral shedding. Viral clearance in these subjects is likely to occur through activation of NK cells. The latter are capable of recognizing CoV-associated, antigen (Ag)-nonspecific patterns on the surface of CoV-infected epithelial target cells. As killing by NK cells is, therefore, not Ag-specific and as seroconversion in asymptomatically infected subjects is only short-lived, viral immune escape does not normally occur. Consequently, new, more infectious, variants are unlikely to emerge from this population as long as viral infectiousness does not dramatically increase.

– However, as long as the point of ‘no immune escape’ isn’t reached, any additional immune selection pressure, for example as a result of suboptimal concentration or affinity of Ag-specific (e.g., spike protein-specific) Abs, will allow the virus to rapidly unfold more infectious, immune escape variants. Additional immune selection pressure, especially when exerted during the second wave of a CoV pandemic, is likely to precipitate and amplify viral immune escape. This might even cause the second and third wave to merge into a single huge wave of mortality and disease that affects all layers of the population (possibly, with the exception of small children).

– Especially mass vaccination campaigns, particularly when conducted in the midst of a pandemic, are prone to exerting enormous immune pressure on circulating virus strains. This is because the vaccine is used in an increasingly infectious context (as escape variants are more infectious). Mass vaccination campaigns will accelerate the emergence of even more infectious immune escape variants. This because the number of vaccine recipients who seroconvert within a given time period will dramatically increase.

– In addition, Ag-specific, high affinity Abs induced by any of the current vaccines will outcompete natural, broadly protective mucosal IgM antibodies as the latter only bind with low affinity to the receptor-binding domain of CoV (RBD). This will particularly affect natural resistance of younger age groups which – thanks to a well-trained innate immune system- resisted disease during the first wave. The new circulating CoV variants may now even be able to escape the host’s CoV variant-nonspecific line of immune defense at the mucosal portal of entry. These age groups may, therefore, become more susceptible to symptomatic infection and shedding caused by more infectious variants.

– But mass vaccination campaigns will also have severe consequences for those who got vaccinated first (mostly the elderly or people with underlying disease or those who are otherwise immunocompromised). In the highly likely event that mass vaccination will soon result in antiviral resistance (see below), these people will have no single bit of immunity left to rely upon. In contrast to the infectious circulating virus, current vaccines do either not contain any critical killer cell motif or fail to activate dedicated killer cells. It goes, therefore, without saying that vaccine-induced immune responses will inevitably result in a dramatic enhancement of morbidity and mortality rates in all of the human population (except for small children?).

– The combination of mass vaccination and infection prevention measures is a recipe for a global health disaster. Following the science, one has to conclude that all age groups (possibly with the exception of small children) will be heavily affected and subject to rates of morbidity and mortality that raise much faster and much higher than those expected to occur during the natural course of a CoV pandemic. This will particularly apply if the sequence of mass vaccinations following the first infectious wave parallels that of natural infection (i.e., immunocompromised people and elderly first, followed by the younger age groups).

– No one, for that matter, should be granted a right to implement large-scale pharmaceutic and non-pharmaceutic immune interventions, especially not during a viral pandemic, and certainly not without an in-depth understanding of the immune pathogenesis of a viral pandemic. When one follows the science, and nothing but the science, it becomes extremely difficult to not label ongoing mass vaccination campaigns as a crime, not only to public health but also to individual health.

– To substantiate the reasoning above, the manuscript will first explain how components of the innate immune system can protect against Covid-19 and render infections asymptomatic. It will then go on to explain in more detail why and how, in an immunologically Covid-19-naïve population, selective (i.e., adaptive) immune escape shifts the first wave of disease and death from the elderly (and immunocompromised) subjects to those who at the outset of the pandemic got away with asymptomatic infection (i.e., the younger and middle-aged population segment). Similarly, it will be explained how viral immune escape in the asymptomatically infected population finally shifts back the burst of morbidity and mortality to the elderly, and how the population eventually controls the pandemic by controlling viral immune escape. This will already illustrate the critical importance of desiccating the changing contribution of innate and adaptive immunity to the population’s overall immune defense against a viral pandemic. Understanding these dynamics helps to comprehend the sophisticated course of a natural CoV pandemic, how it eventually merges into an endemic infection and why human intervention has a highly detrimental impact on the refined interplay between the virus and its host. In regard of the latter, the devastating global health impact of ongoing mass vaccination campaigns and accompanying stringent and widespread containment measures will be explained in more detail as the global and individual health consequences could simply be unbearable for many years to come.

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The HighWire with Del Bigtree – “A COMING COVID CATASTROPHE”

****This video is of absolute critical importance!! Please set aside the 1 hour, 5 minutes to watch this video in its entirety! It will help you understand in easy to understand terms exactly why Geert Van Bossche is stating the mass vaccinations will result in mass casualties among all humans of all ages!****

“World renown vaccine specialist, Geert Vanden Bossche, gave a groundbreaking interview this week risking his reputation and his career by bravely speaking out against administration of #Covid19 vaccines. In what may be one of the most important stories ever covered, the vaccine developer shared his extreme concerns about these vaccines in particular and why we may be on track to creating a global immunity catastrophe.”

– Anytime there is a pandemic, the elderly get infected first. The vulnerable need to be protected because they no longer have innate immunity.

– The young people should not have been locked down.

– These are prophylactic vaccines which should not be used